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ML351

CID 664510

Technical Data

Chemical name:ML351
Formula:C15H11N3O
Molecular weight:249.3
CAS number:847163-28-4
SMILES:CNc1oc(nc1C#N)-c1cccc2ccccc12

Cat. No. BRC0903

BRC0903

Prices

1.0 mg $ 83.0
2.0 mg $ 85.0
5.0 mg $ 90.0
10.0 mg $ 117.0
20.0 mg $ 160.0
25.0 mg $ 180.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents    Cardiovascular    CNS Agents    Antiparkinson   

Target:

Enzymes    Lipoxygenases   

Description:

ML351 is selective inhibitor of 12/15-lipoxygenase. It was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.

Targets:Arachidonate 15-lipoxygenase, Arachidonate 12-lipoxygenase
References:
1. J. Med. Chem. 2014; 57, 10, 4035 - 4048.; 
2. J. Med. Chem. 2015; 58, 19, 7850 - 7862.; 
3. Bioorg. Med. Chem. 2016; 24(21), 5380-5387.;