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Primidone

Desoxyphenobarbital, Mysoline, Liskantin, Mizodin, Mylepsinum, Pridona, Primid, Prysoline, Sertan

Technical Data

Chemical name:Primidone
Formula:C12H14N2O2
Molecular weight:218.3
CAS number:125-33-7
SMILES:CCC1(C(=O)NCNC1=O)c1ccccc1

Cat. No. BRC0226

BRC0226

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anticonvulsants    CNS Agents   

Target:

G-Protein-Coupled Receptors (GPCRs)    Glutamate receptor    GABA receptors    Ion Channels    Sodium channel    Ligand-gated ion channels    Transporters    Ion Pumps   

Description:

An antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Primidone is a GABA receptor agonist.

Targets:Gamma-aminobutyric acid receptor subunit alpha-1-6, Neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit alpha-7, Glutamate receptor 2, Glutamate receptor ionotropic, kainate 2, GABA-A receptor (anion channel)
References:
1. Curr Treat Options Neurol. 2000 Nov; 2(6):527-542.; 
2. Pediatr Neurol. 2002 Jan; 26(1):55-60.; 
3. Lancet. 1993 Oct 9; 342(8876):925.; 
4. Ann Clin Psychiatry. 1999 Jun; 11(2):61-6.; 
5. Acta Paediatr Scand. 1991 Jan; 80(1):120-4.;