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Anagrelide hydrochloride

BL-4162A, Xagrid

Technical Data

Chemical name:Anagrelide hydrochloride
Formula:C10H8Cl3N3O
Molecular weight:292.5
CAS number:58579-51-4
SMILES:Cl.Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl |t:5|

Cat. No. BRC0655

BRC0655

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents    Cardiovascular   

Target:

Enzymes    Phosphodiesterases (PDE)    Platelet Aggregation inhibitors   

Description:

Anagrelide hydrochloride is a potent PDE3 (type III phosphodiesterase) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

Targets:cGMP-inhibited 3',5'-cyclic phosphodiesterase A
References:
1. Br J Pharmacol. 2005; 146, 3, 324.; 
2. J. Med. Chem. 1991; 34, 9, 2906.; 
3. Curr Top Med Chem. 2007; 7, 4, 421.;