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JW74

Technical Data

Chemical name:JW74
Formula:C24H20N6O2S
Molecular weight:456.5
CAS number:863405-60-1
SMILES:COc1ccc(cc1)-n1c(SCc2nc(no2)-c2ccc(C)cc2)nnc1-c1ccncc1

Cat. No. BRC0766

BRC0766

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 140.0
25.0 mg $ 160.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

Enzymes    Cytochrome P450 (CYP)    MYC (c-Myc, proto-oncogene proteins)   

Description:

JW 74 is an inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3 beta /AXIN/APC). Decreases active β-catenin levels in colorectal cancer (CRC) cells. Also, arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro.

Targets:Tankyrase-1, Tankyrase-2, Axin-2, Proto-oncogene Wnt-1, Wingless-Type Mmtv Integration Site Family, Member 3, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4
References:
1. Cancer Res. 2011; 71(1), 197-205.; 
2. J. Med. Chem. 2012; 55(3), 1127-1136.; 
3. J. Med. Chem. 2012; 55(3), 1127-1136.;