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Norfloxacin

MK-0366

Technical Data

Chemical name:Norfloxacin
Formula:C16H18FN3O3
Molecular weight:319.3
CAS number:70458-96-7
SMILES:CCn1cc(C(O)=O)c(=O)c2cc(F)c(cc12)N1CCNCC1

Cat. No. BRC0364

BRC0364

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents    Anti-infective    Antibacterial   

Target:

Enzymes    Topoisomerase    DNA    SUBDNA   

Description:

Norfloxacin is a quinolone/fluoroquinolone antibiotic. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two.

Targets:DNA gyrase subunit A, DNA topoisomerase 4 subunit A, DNA topoisomerase 2-alpha
References:
1. Am J Med. 1987 Jun 26; 82(6B):3-17.; 
2. J. Med. Chem. 1980; 23, 1358.; 
3. Antimicrob. Agents Chemother. 1981; 19, 188.; 
4. Drugs. 1985; 30, 482.;