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Rhosin hydrochloride

Technical Data

Chemical name:Rhosin hydrochloride
Formula:C20H19ClN6O
Molecular weight:394.9
CAS number:
SMILES:Cl.N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN=Cc1ccc2nccnc2c1

Cat. No. BRC0833

BRC0833

Prices

1.0 mg $ 93.0
2.0 mg $ 96.0
5.0 mg $ 100.0
10.0 mg $ 131.0
20.0 mg $ 253.0
25.0 mg $ 295.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

Kinases    Rho-associated protein kinase (ROCK)    Kinases    Enzyme-Linked Receptors    Receptor protein serine/threonine kinases   

Description:

Rhosin hydrochloride is Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF.

Targets:Rho-dependent protein serine/threonine kinase,
References:
1. Chem Biol. 2012; 19(6), 699-710.; 
2. Proc Natl Acad Sci U S A. 2013; 110(8), 3155-3160, S3155/1-S3155/8.; 
3. Br J Cancer. 2016; 115(3), 364-370.;