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Tyrphostin AG-1295

AG-1295, NSC 380341

Technical Data

Chemical name:Tyrphostin AG-1295
Formula:C16H14N2
Molecular weight:234.3
CAS number:71897-07-9
SMILES:Cc1cc2ncc(nc2cc1C)-c1ccccc1

Cat. No. BRC0630

BRC0630

Prices

1.0 mg $ 85.0
2.0 mg $ 87.0
5.0 mg $ 92.0
10.0 mg $ 120.0
20.0 mg $ 220.0
25.0 mg $ 260.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Kinases    Vascular endothelial growth factor (VEGF)    Platelet-derived growth factor (PDGF)    Kinases    Enzyme-Linked Receptors    Receptor Tyrosine Kinase   

Description:

Tyrphostin AG 1295 is a cell-permeable, reversible, ATP-competitive and selective inhibitor of PDGFR (platelet-derived growth factor receptor) protein tyrosine kinase (PDGF-receptor PTK)(IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 μM) in Swiss/3T3 cells, and demonstrates about 50% inhibition on neointimal formation after balloon injury in porcine femoral arteries.

Targets:Platelet-derived growth factor receptor, Tyrosine-protein kinase receptor FLT3, Platelet-derived growth factor receptor beta, Vascular endothelial growth factor receptor 2,
References:
1. ChemMedChem. 2015; 10, 3, 511 - 522.; 
2. Bioorg. Med. Chem. 2003; 11, 9, 2007 - 2018.; 
3. Cancer Res. 1994; 54(23), 6106-14.;