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SRPIN340

Technical Data

Chemical name:SRPIN340
Formula:C18H18F3N3O
Molecular weight:349.4
CAS number:218156-96-8
SMILES:FC(F)(F)c1ccc(N2CCCCC2)c(NC(=O)c2ccncc2)c1

Cat. No. BRC0575

BRC0575

Prices

1.0 mg $ 83.0
2.0 mg $ 85.0
5.0 mg $ 90.0
10.0 mg $ 117.0
20.0 mg $ 150.0
25.0 mg $ 170.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antiviral    Anti-infective   

Target:

Kinases    Vascular endothelial growth factor (VEGF)    Kinases    Enzyme-Linked Receptors    Receptor Tyrosine Kinase   

Description:

SRPIN 340 is selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. SRPIN 340 is competitive with ATP and does not inhibit other SRPKs significantly.

Targets:Protein kinase SRPK1, Protein kinase SRPK2, Vascular endothelial growth factor
References:
1. Antimicrob. Agents Chemother. 2010; 54(8), 3179-3186.; 
2. PLoS One. 2011; 6(8), e23246.; 
3. Oncogene. 2015; 34(33), 4311-4319.;