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Agmatine sulfate

NIH 11035; NSC 56332;

Technical Data

Chemical name:Agmatine sulfate
Formula:C5H16N4O4S
Molecular weight:228.3
CAS number:2482-00-0
SMILES:OS(O)(=O)=O.NCCCCNC(N)=N

Cat. No. BRC1320

BRC1320

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

G-Protein-Coupled Receptors (GPCRs)    Adrenergic receptor    Glutamate receptor    Enzyme-Linked Receptors    Cytokine receptors    Ion Channels    Calcium channel    Ligand-gated ion channels   

Description:

Agmantine is a natural metabolite of the arginine. It binds to human adrenergic receptors and imidazoline (I) receptors. Agmatine acts as an antagonist of the NMDA receptor and nicotinic acetylcholine receptors. It is an antagonist of the serotonin receptor subtype 5-HT3 and blocks ATP-sensitive potassium channels. Agmatine competitively inhibits neuronal, macrophage, endothelial, and inducible nitric oxide synthase and irreversibly inactivates neuronal NOS in the presence of calmodulin.

Targets:Imidazoline 2 receptor; Nischarin; Spermine oxidase; alpha2-adrenergic receptor; Voltage-dependent N-type calcium channel subunit alpha-1B; Glutamate receptor ionotropic, NMDA 2D; Multidrug and toxin extrusion protein 1; Deoxyhypusine synthase; Ornithine decarboxylase; Nitric oxide synthase; Tumor necrosis factor α;
References:
1. Bioorganic Med. Chem. 1996; 4, 9, 1559 - 1564.; 2. Med. Res. Rev. 2004; 24, 5, 639 - 661.; 3. J. Med. Chem. 2009; 52, 15, 4774 - 4785.;