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SP2509

HCI-2509, LSD1 Inhibitor VII

Technical Data

Chemical name:SP2509
Formula:C19H20ClN3O5S
Molecular weight:437.9
CAS number:1287421-04-8
SMILES:CC(=NNC(=O)c1cccc(c1)S(=O)(=O)N1CCOCC1)c1cc(Cl)ccc1O

Cat. No. BRC0500

BRC0500

Prices

1.0 mg $ 83.0
2.0 mg $ 86.0
5.0 mg $ 91.0
10.0 mg $ 118.0
20.0 mg $ 170.0
25.0 mg $ 190.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

Enzymes    Amine oxidase    Histone Demethylase   

Description:

SP2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM) showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase.

Targets:Amine oxidase [flavin-containing] A, Amine oxidase [flavin-containing] B, Lysine-specific histone demethylase 1A
References:
1. J. Med. Chem. 2013; 56(23), 9496-9508.; 
2. PCT Int. Appl. 2013; WO 2013025805 A1 20130221.; 
3. PCT Int. Appl. 2017; WO 2017097865 A1 20170615.;