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Procaine Hydrochloride

Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;

Technical Data

Chemical name:Procaine Hydrochloride
Molecular weight:272.8
CAS number:51-05-8

Cat. No. BRC0941



1.0 mg $ 57.0
2.0 mg $ 58.0
5.0 mg $ 62.0
10.0 mg $ 82.0
20.0 mg $ 98.0
25.0 mg $ 105.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antiemetic agents    CNS Agents   


G-Protein-Coupled Receptors (GPCRs)    Dopamine receptor    5-hydroxytryptamine receptor (5-HT receptor) inhibitors    Glutamate receptor    Enzymes    Lipases    Monoamine oxidases (MAO)    Amine oxidase    Ion Channels    Potassium channel    Sodium channel    Ligand-gated ion channels    DNA    SUBDNA    Transporters    Ion Pumps    Neurotransmitter transporter   


Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.

Targets:Sodium channel protein type 10 subunit alpha; Glutamate receptor ionotropic, NMDA 3A; 5-hydroxytryptamine receptor 3A; Sodium-dependent dopamine transporter; Neuronal acetylcholine receptor subunit alpha-2; DNA; Calcium-activated potassium channel; Phospholipase A2; Lysophospholipase; Monoamine oxidase;
1. J Med Chem. 2010; 53, 12, 4668 - 4677.; 2. Pharmacology. 2005; 74, 2, 65 - 78.; 3. Eur J Med Chem. 2013; 65, 304 - 314.;