Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;
|Chemical name:||Procaine Hydrochloride|
Cat. No. BRC0941
|It belongs to next groups of Bioreference compounds:|
G-Protein-Coupled Receptors (GPCRs) Dopamine receptor 5-hydroxytryptamine receptor (5-HT receptor) inhibitors Glutamate receptor Enzymes Lipases Monoamine oxidases (MAO) Amine oxidase Ion Channels Potassium channel Sodium channel Ligand-gated ion channels DNA SUBDNA Transporters Ion Pumps Neurotransmitter transporter
Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.
|Targets:||Sodium channel protein type 10 subunit alpha; Glutamate receptor ionotropic, NMDA 3A; 5-hydroxytryptamine receptor 3A; Sodium-dependent dopamine transporter; Neuronal acetylcholine receptor subunit alpha-2; DNA; Calcium-activated potassium channel; Phospholipase A2; Lysophospholipase; Monoamine oxidase;|
1. J Med Chem. 2010; 53, 12, 4668 - 4677.; 2. Pharmacology. 2005; 74, 2, 65 - 78.; 3. Eur J Med Chem. 2013; 65, 304 - 314.;