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Perfluorooctanoic acid

A 5717; EF 201; Eftop EF 201; NSC 95114; PFOA;

Technical Data

Chemical name:Perfluorooctanoic acid
Formula:C8HF15O2
Molecular weight:414.1
CAS number:335-67-1
SMILES:OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

Cat. No. BRC1281

BRC1281

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Enzymes    Phosphatases    Enzyme-Linked Receptors    Receptor Tyrosine Kinase    Nuclear Receptors (nuclear hormone receptors)    Androgen receptor    DNA    SUBDNA   

Description:

Perfluorooctanoic acid is one of the most commonly used perfluorinated compounds, it causes hepatic peroxisome proliferation in rodents. It may have toxic effects on the immune system, liver, development, and endocrine systems through alteration of DNA methylation enzymes.

Targets:Estrogen receptor; Liver fatty acid binding protein; Tyrosine-protein phosphatase non-receptor type 11; DNA polymerase alpha; DNA nucleotidylexotransferase; Androgen receptor;
References:
1. Toxicol. In Vitro. 2017; 45, 146 - 157.; 2. Arch. Toxicol. 2016; 90, 1, 217 - 227.; 3. Org. Biomol. Chem. 2007; 5, 24, 3912 - 3921.;