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Indomethacin

Indocin

Technical Data

Chemical name:Indomethacin
Formula:C19H16ClNO4
Molecular weight:357.8
CAS number:53-86-1
SMILES:COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1

Cat. No. BRC0367

BRC0367

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Analgesics    Anti-Inflammatory    Cardiovascular    CNS Agents   

Target:

Enzymes    Cyclooxygenase (COX)    Reductases    Nuclear Receptors (nuclear hormone receptors)    Peroxisome proliferator-activated receptor (PPAR)   

Description:

Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

Targets:Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2, Phospholipase A2, membrane associated, Prostaglandin reductase 2, Peroxisome proliferator-activated receptor gamma, Lactoylglutathione lyase, Prostaglandin D2 receptor 2, Peroxisome proliferator-activated receptor alpha
References:
1. Prostaglandins Leukot. Med. 1984; 13: 53-60.; 
2. J. Biol. Chem. 1993; 268: 6610-6614.; 
3. J. Biol. Chem. 1997; 272: 3406-3410.; 
4. South Med J. 1985 Jun; 78(6):756-7.; 
5. Br Med J. 1963 Oct 19; 2(5363):965-70.; 
6. J Clin Invest. 1977 Jan; 59(1):8-13.;