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Lanicemine

ARL 15896; FPL 15896; AR-R15896; AZD6765;

Technical Data

Chemical name: Lanicemine
Formula:C13H14N2
Molecular weight:198.3
CAS number:153322-05-5
SMILES:N[C@@H](CC1=NC=CC=C1)C1=CC=CC=C1

Cat. No. BRC1074

BRC1074

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

CNS Agents    Antidepressive Agents   

Target:

G-Protein-Coupled Receptors (GPCRs)    Glutamate receptor    Ion Channels    Ligand-gated ion channels    Transporters    Ion Pumps   

Description:

Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM). It has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment-Resistant Major Depressive Disorder.

Targets:Glutamate receptor ionotropic, NMDA 2D;
References:
1. Brain Res. 2006; 1114, 1, 36 - 40.; 2. Eur J Pharmacol. 2002; 443, 1-3, 79 - 83.; 3. Bioorg Med Chem. 2009; 17, 9, 3456 - 3462.;