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Propranolol hydrochloride

AY-64043, ICI-45520, NCS-91523, Angilol, Bedranol SR, Cardinol, Ciplar, Deralin, Dociton, Duranol, HEMANGEOL, Inderal, Inderal LA, Indobloc, INNOPRAN, Innopran XL, Prophylux, Sumial

Technical Data

Chemical name:Propranolol hydrochloride
Formula:C16H22ClNO2
Molecular weight:295.8
CAS number:318-98-9
SMILES:Cl.CC(C)NCC(O)COc1cccc2ccccc12

Cat. No. BRC0428

BRC0428

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-arrhythmia agents    Antihypertensive    Cardiovascular   

Target:

G-Protein-Coupled Receptors (GPCRs)    Adrenergic receptor    5-hydroxytryptamine receptor (5-HT receptor) inhibitors    Ion Channels    Ligand-gated ion channels    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

Targets:Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, Beta-3 adrenergic receptor, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1B
References:
1. J. Pharmacol. Exp. Ther. 1982; 223(1), 50 - 54.; 
2. J. Med. Chem. 1973; 16(11), 1245 - 1251.; 3.Br. J. Pharmacol. 2005; 144(3), 317-322.; 
4. J. Pharm. Pharm. Sci. 2001; 4(2), 185-200.; 5.Br. J. Pharmacol. 1978; 64(2), 193-200.; 
6. West.J.Med. 1980; 132(5), 430-439.;