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Flufenamic acid

Arlef, CI 440, CN 27544, INF 1837, NSC 219007, NSC 82699

Technical Data

Chemical name:Flufenamic acid
Formula:C14H10F3NO2
Molecular weight:281.2
CAS number:530-78-9
SMILES:OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F

Cat. No. BRC0479

BRC0479

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Analgesics    Anti-cancer agents    Anti-Inflammatory   

Target:

Enzymes    Cyclooxygenase (COX)    Reductases    Nuclear Receptors (nuclear hormone receptors)    Peroxisome proliferator-activated receptor (PPAR)    Androgen receptor   

Description:

Flufenamic acid is an anthranilic acid-derived nonsteroidal anti-inflammatory drug (NSAID) thought to exert its actions by a prostanoid-independent mechanism.

Targets:Prostaglandin G/H synthase 2, Prostaglandin G/H synthase 1, Aldo-keto reductase family 1 member C3, Androgen receptor, Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor gamma, Cyclooxygenase
References:
1. Proc Natl Acad Sci U S A. 1999; 96(13), 7563-7568.; 
2. J. Biol. Chem. 1997; 272(6), 3406-3410.; 
3. Circ Res. 2001; 88(3), 325-332.;