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Chlorothiazide

Diutrid, Flumen, Minzil, NSC 25693, Alurene, Chlorosal

Technical Data

Chemical name:Chlorothiazide
Formula:C7H6ClN3O4S2
Molecular weight:295.7
CAS number:58-94-6
SMILES:NS(=O)(=O)c1cc2c(cc1Cl)N=CNS2(=O)=O |c:12|

Cat. No. BRC0651

BRC0651

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antihypertensive    Cardiovascular   

Target:

Enzymes    Carbonic Anhydrase    Solute carrier family (SLC)   

Description:

Chlorothiazide is an inhibitor of carbonic anhydrase (IC50 = 0.06 µM). This compound has been shown to block reabsorption of sodium and chloride ions.

Targets:Solute carrier family 12 member 3, Carbonic anhydrase 1, Carbonic anhydrase 2, Carbonic anhydrase 4
References:
1. Eur. J. Med. Chem. 1996; 31, 11, 843.; 
2. Br J Pharmacol. 2008; 155, 7, 1066.; 
3. Eur. J. Med. Chem. 1997; 32, 4, 311.;