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Theophylline

Elixophyllin, Respbid, Theo-dur, Theolair, Uniphyl

Technical Data

Chemical name:Theophylline
Formula:C7H8N4O2
Molecular weight:180.2
CAS number:75448-53-2
SMILES:Cn1c2nc[nH]c2c(=O)n(C)c1=O

Cat. No. BRC0251

BRC0251

Prices

1.0 mg $ 57.0
2.0 mg $ 58.0
5.0 mg $ 62.0
10.0 mg $ 82.0
20.0 mg $ 98.0
25.0 mg $ 105.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Cardiovascular    CNS Agents    Neurotransmitter Agents   

Target:

G-Protein-Coupled Receptors (GPCRs)    Adenosine receptor    Enzymes    Histone deacetylases (HDAC)    Phosphodiesterases (PDE)    Transporters    Ion Pumps   

Description:

Theophylline, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Theophylline has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

Targets:Adenosine receptor A1, Adenosine receptor A2a, Adenosine receptor A2b, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cGMP-specific 3',5'-cyclic phosphodiesterase, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, Histone deacetylase 2,
References:
1. Am.J.Respir.Care Med. 2003; 167, 813.; 
2. J.Clin.Pharmacol. 1999; 39, 237.; 
3. Clin.Exp.Allery. 1998; 28 (Suppl. 3), 42.;