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Orotic Acid

NSC 79560; NSC 9791; Animal galactose factor;

Technical Data

Chemical name:Orotic Acid
Formula:C5H4N2O4
Molecular weight:156.1
CAS number:65-86-1
SMILES:OC(=O)C1=CC(=O)NC(=O)N1

Cat. No. BRC1013

BRC1013

Prices

1.0 mg $ 86.0
2.0 mg $ 88.0
5.0 mg $ 94.0
10.0 mg $ 121.0
20.0 mg $ 146.0
25.0 mg $ 159.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Enzymes    Dehydrogenase   

Description:

Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid, forming pyrophosphate and orotidine 5′-monophosphate (OMP). It may be used to study dependent cell signaling pathways and transcription regulation mechanisms that induce hepatic lipogenesis.

Targets:Orotate phosphoribosyltransferase; Dihydroorotate dehydrogenase (quinone), mitochondrial; Dihydroorotate dehydrogenase (quinone); Dihydroorotase; Dihydroorotate dehydrogenase A (fumarate);
References:
1. J Med Chem. 2001; 44, 18, 2861 - 2864.; 2.  Eur J Med Chem. 2010; 45, 12, 5899 - 5909.; 3. Biochemistry. 1991; 30, 7, 1934 - 1939.;