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SMI-4a

TCS PIM-1 4a

Technical Data

Chemical name:SMI-4a
Formula:C11H6F3NO2S
Molecular weight:273.2
CAS number:327033-36-3
SMILES:FC(F)(F)c1cccc(C=C2SC(=O)NC2=O)c1

Cat. No. BRC0510

BRC0510

Prices

1.0 mg $ 83.0
2.0 mg $ 86.0
5.0 mg $ 91.0
10.0 mg $ 118.0
20.0 mg $ 170.0
25.0 mg $ 190.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

Kinases    Proviral integration of MMLV kinases (PIM)    Other kinases    Kinases   

Description:

SMI-4a is a potent selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2. Does not significantly inhibit any other serine/threonine- or tyrosine-kinases.

Targets:Protein kinase Pim-1
References:
1. Bioorg. Med. Chem. 2002; 10(4), 1077-1084.; 
2. J. Med. Chem. 2009; 52(1), 74-86.; 
3. Bioorg. Med. Chem Letters. 2005; 15(17), 3930-3933.;