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Gabapentin

Gabapentin GR, Neurontin, Aclonium

Technical Data

Chemical name:Gabapentin
Formula:C9H17NO2
Molecular weight:171.2
CAS number:60142-96-3
SMILES:NCC1(CC(O)=O)CCCCC1

Cat. No. BRC0189

BRC0189

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Analgesics    Anticonvulsants    Cardiovascular   

Target:

G-Protein-Coupled Receptors (GPCRs)    Adenosine receptor    Ion Channels    Calcium channel    Ligand-gated ion channels    Transporters    Ion Pumps   

Description:

Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.

Targets:Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-dependent N-type calcium channel subunit alpha-1B, Adenosine receptor A1, NMDA receptor
References:
1. Headache. 2001 Feb; 41(2):119-28.; 
2. Pain Med. 2004 Mar; 5 Suppl 1:S28-47.; 
3. Eye (Lond). 2007 Sep; 21(9):1194-7.; 
4. Bipolar Disord. 2000 Sep; 2(3 Pt 2):249-55.; 
5. J Pharmacol Exp Ther. 2005 Jun; 313(3):1406-15.;