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Felodipine

CGH-869, Felodur ER, Felogard, Plendil Depottab, Plendil ER, Plendil Retard, Renedil, Splendil, Agon, H 154/82

Technical Data

Chemical name:Felodipine
Formula:C18H19Cl2NO4
Molecular weight:384.2
CAS number:72509-76-3
SMILES:CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC |c:5,10|

Cat. No. BRC0417

BRC0417

Prices

1.0 mg $ 83.0
2.0 mg $ 86.0
5.0 mg $ 91.0
10.0 mg $ 118.0
20.0 mg $ 175.0
25.0 mg $ 195.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-arrhythmia agents    Antihypertensive    Cardiovascular   

Target:

Enzymes    Phosphodiesterases (PDE)    Ion Channels    Calcium channel    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction.

Targets:Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent L-type calcium channel subunit beta-2, Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-dependent T-type calcium channel subunit alpha-1H, Voltage-dependent calcium channel subunit alpha-2/delta-2, Calmodulin, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Mineralocorticoid receptor, Troponin C, skeletal muscle, Troponin C, slow skeletal and cardiac muscles
References:
1. Drug Metab. Dispos. 2011; 39(1), 151 – 159.; 
2. J. Pharm. Pharmacol. 1999; 51(6), 709 - 714.;