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Brimonidine

UK 14,304

Technical Data

Chemical name:Brimonidine
Formula:C11H10BrN5
Molecular weight:292.1
CAS number:59803-98-4
SMILES:Brc1c(NC2=NCCN2)ccc2nccnc12 |t:4|

Cat. No. BRC0350

BRC0350

Prices

1.0 mg $ 83.0
2.0 mg $ 85.0
5.0 mg $ 90.0
10.0 mg $ 117.0
20.0 mg $ 160.0
25.0 mg $ 180.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antihypertensive    Cardiovascular    CNS Agents   

Target:

G-Protein-Coupled Receptors (GPCRs)    Adrenergic receptor   

Description:

Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2).

Targets:Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-2C adrenergic receptor
References:
1. J.Pharmacol.Exp.Ther. 1999; 288, 798.; 
2. TiPS. 1997; 18, 211.; 
3. Life Sci. 1988; 43, 1805.;