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Lidocaine

ALGRX-3268; LSM-3165; NSC-40030;

Technical Data

Chemical name:Lidocaine
Formula:C14H22N2O
Molecular weight:234.3
CAS number:137-58-6
SMILES:CCN(CC)CC(=O)NC1=C(C)C=CC=C1C

Cat. No. BRC0967

BRC0967

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-arrhythmia agents    Cardiovascular    CNS Agents   

Target:

Enzyme-Linked Receptors    Receptor Tyrosine Kinase    Ion Channels    Sodium channel    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Lidocaine is an anaesthetic agent and class Ib antiarrhythmic agent. It is a selective inverse peripheral histamine H1-receptor agonist. This compound is known to block voltage-gated sodium channels in the inactivated state.

Targets:Sodium channel protein type 10 subunit alpha; Sodium channel protein type 9 subunit alpha; Sodium channel protein type 5 subunit alpha; Epidermal growth factor receptor; Sodium channel protein type 4 subunit alpha; Alpha-1-acid glycoprotein 1; Alpha-1-acid glycoprotein 2;
References:
1. J Med Chem. 2010; 53, 12, 4668 - 4677.; 2. Br J Pharmacol. 2001; 133, 1, 207 - 216.; 3. Eur J Med Chem. 2014; 74, 23 - 30.;