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Haloperidol

MCN-JR-1625; NSC-170973; NSC-615296; R-1625; Dozic; Einalon S; Eukystol;

Technical Data

Chemical name:Haloperidol
Formula:C21H23ClFNO2
Molecular weight:375.9
CAS number:52-86-8
SMILES:OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

Cat. No. BRC0730

BRC0730

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antiemetic agents    CNS Agents    Neurotransmitter Agents    Antipsychotics   

Target:

G-Protein-Coupled Receptors (GPCRs)    Dopamine receptor    5-hydroxytryptamine receptor (5-HT receptor) inhibitors    Glutamate receptor    Ion Channels    Ligand-gated ion channels    Transporters    Ion Pumps    Neurotransmitter transporter    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Haloperidol is butyrophenone antipsychotic, D2, D3, and D4 dopamine receptor antagonist. It is used primarily to treat schizophrenia and other psychoses.

Targets:D(2) dopamine receptor; Glutamate receptor ionotropic, NMDA 2B; D(1A) dopamine receptor; 5-hydroxytryptamine receptor 2A; D(3) dopamine receptor; Synaptic vesicular amine transporter;
References:
1. Biochem. Pharmacol. 2004; 68, 4, 761.; 2. J. Med. Chem. 2014; 57, 16, 7042.; 3. Br J Pharmacol. 2005; 145, 1, 34.;