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A 22 hydrochloride

Technical Data

Chemical name:A 22 hydrochloride
Formula:C8H9Cl3N2S
Molecular weight:271.6
CAS number:22816-60-0
SMILES:Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1

Cat. No. BRC0503

BRC0503

Prices

1.0 mg $ 86.0
2.0 mg $ 88.0
5.0 mg $ 94.0
10.0 mg $ 121.0
20.0 mg $ 146.0
25.0 mg $ 159.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-infective   

Target:

Kinases    RAF kinases    Kinases    Enzyme-Linked Receptors    Receptor protein serine/threonine kinases    MYC (c-Myc, proto-oncogene proteins)   

Description:

A22 s a cell-permeable isothiourea compound that inhibits MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant.

Targets:Indoleamine 2,3-dioxygenase, RAF proto-oncogene serine/threonine-protein kinase, MreB
References:
1. Bioorg Med Chem Lett. 2010; 20:5126-5129.; 
2. Cell. 2005; 120(3), 329-341.; 
3. Genes Dev. 2006; 20(1), 113-124.; 
4. WO2007062222 (A2) ― 2007-05-31.;