BIO
GSK 3 Inhibitor IX; MLS 2052; 6-Bromoindirubin-3-oxime;
Technical Data
| Chemical name: | BIO |
| Formula: | C16H10BrN3O2 |
| Molecular weight: | 356.2 |
| CAS number: | 710323-58-3 |
| SMILES: | ON=C1C(NC2=C1C=CC=C2)=C1C(=O)NC2=C1C=CC(Br)=C2 |
Cat. No. BRC0793
Prices
Biological activity
| It belongs to next groups of Bioreference compounds: | |
| Target: | Kinases Mitogen-activated protein kinase (MAPK) Src kinases Cyclin-dependent protein kinases (CDK) Kinases Enzyme-Linked Receptors Receptor protein serine/threonine kinases Receptor Tyrosine Kinase MYC (c-Myc, proto-oncogene proteins) |
| Description: | BIO is a cell-permeable, highly potent, selective, reversible and ATP-competitive glycogen synthase kinase-3 inhibitor. Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro. Also, promotes proliferation and dedifferentiation in cardiomyocytes. |
| Targets: | Glycogen synthase kinase-3 beta; Glycogen synthase kinase-3 alpha; CDK5/Cyclin (Cyclin B); Aryl hydrocarbon receptor nuclear translocator; Tyrosine-protein kinase Fgr; Receptor-type tyrosine-protein kinase FLT3; Proto-oncogene tyrosine-protein kinase receptor Ret; NT-3 growth factor receptor; Tyrosine-protein kinase Lyn; Proto-oncogene tyrosine-protein kinase Src; CDK2/Cyclin (Cyclin A); Abelson tyrosine-protein kinase 2; Mitogen-activated protein kinase kinase kinase 9; BDNF/NT-3 growth factors receptor; CDK3/Cyclin (Cyclin E); |
| References: | 1. Nat Biotechnol. 2011; 29(11), 1039-1045.; 2. J. Med. Chem. 2004; 47(4), 935-946.; 3. J. Med. Chem. 2012; 55(21), 9312-9330.; |