Welcome, Guest

Return to Search menu


GSK 3 Inhibitor IX; MLS 2052; 6-Bromoindirubin-3-oxime;

Technical Data

Chemical name:BIO
Molecular weight:356.2
CAS number:710323-58-3

Cat. No. BRC0793



1.0 mg $ 88.0
2.0 mg $ 91.0
5.0 mg $ 96.0
10.0 mg $ 125.0
20.0 mg $ 240.0
25.0 mg $ 280.0

Make inquiry

Biological activity

It belongs to next groups of Bioreference compounds:

Kinases    Mitogen-activated protein kinase (MAPK)    Src kinases    Cyclin-dependent protein kinases (CDK)    Kinases    Enzyme-Linked Receptors    Receptor protein serine/threonine kinases    Receptor Tyrosine Kinase    MYC (c-Myc, proto-oncogene proteins)   


BIO is a cell-permeable, highly potent, selective, reversible and ATP-competitive glycogen synthase kinase-3 inhibitor. Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro. Also, promotes proliferation and dedifferentiation in cardiomyocytes.

Targets:Glycogen synthase kinase-3 beta; Glycogen synthase kinase-3 alpha; CDK5/Cyclin (Cyclin B); Aryl hydrocarbon receptor nuclear translocator; Tyrosine-protein kinase Fgr; Receptor-type tyrosine-protein kinase FLT3; Proto-oncogene tyrosine-protein kinase receptor Ret; NT-3 growth factor receptor; Tyrosine-protein kinase Lyn; Proto-oncogene tyrosine-protein kinase Src; CDK2/Cyclin (Cyclin A); Abelson tyrosine-protein kinase 2; Mitogen-activated protein kinase kinase kinase 9; BDNF/NT-3 growth factors receptor; CDK3/Cyclin (Cyclin E);
1. Nat Biotechnol. 2011; 29(11), 1039-1045.; 2. J. Med. Chem. 2004; 47(4), 935-946.; 3. J. Med. Chem. 2012; 55(21), 9312-9330.;