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Erlotinib hydrochloride

CP358774, NSC 718781

Technical Data

Chemical name:Erlotinib hydrochloride
Formula:C22H24ClN3O4
Molecular weight:429.9
CAS number:183319-69-9
SMILES:Cl.COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC

Cat. No. BRC0331

BRC0331

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

Kinases    Epidermal growth factor receptor (EGFR)    Other kinases    Kinases    Enzyme-Linked Receptors    Receptor Tyrosine Kinase    Multidrug Transporter Inhibitors    Breast Cancer Resistance Protein (BCRP)   

Description:

Erlotinib inhibits the intracellular phosphorylation of tyrosine kinase associated with the epidermal growth factor receptor (EGFR).

Targets:Epidermal growth factor receptor, Nuclear receptor subfamily 1 group I member 2
References:
1. Drugs. 2000; 60 Suppl 1:15-23; discussion 41-2.; 
2. J Biol Chem. 2007 Feb 9; 282(6):3428-32.; 
3. Lung Cancer. 2006 Jan; 51(1):89-96.; 
4. Endocr Relat Cancer. 2004 Dec; 11(4):793-814.; 
5. Biochemistry. 2000 Dec 26; 39(51):15705-12.;