DHCA; NSC 57197; NSC 623438;
|Chemical name:||Caffeic Acid|
Cat. No. BRC1022
|It belongs to next groups of Bioreference compounds:|
Caffeic Acid is an endogenous phenolic phytochemical compound. It non-competitive inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. It is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.
|Targets:||linoleate 9s-lipoxygenase 1; arachidonate 5-lipoxygenase; Matrix metalloproteinase-9; 72kDa type IV collagenase; catechol O-methyltransferase; Interstitial collagenase; xanthine dehydrogenase;|
1. Bioorg Med Chem Lett. 2013; 23, 2, 574 - 578.; 2. Curr Med Chem. 2011; 18, 6, 808 - 829.; 3. J Med Chem. 2016; 59, 16, 7584 - 7597.;