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Caffeic Acid

DHCA; NSC 57197; NSC 623438;

Technical Data

Chemical name:Caffeic Acid
Formula:C9H8O4
Molecular weight:180.2
CAS number:331-39-5
SMILES:OC(=O)C=CC1=CC=C(O)C(O)=C1

Cat. No. BRC1022

BRC1022

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents    Antidiabetic    Anti-Inflammatory    Antiviral    Anti-infective    Antibacterial   

Target:

Enzymes    Dehydrogenase    Lipoxygenases   

Description:

Caffeic Acid is an endogenous phenolic phytochemical compound. It non-competitive inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. It is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.

Targets:linoleate 9s-lipoxygenase 1; arachidonate 5-lipoxygenase; Matrix metalloproteinase-9; 72kDa type IV collagenase; catechol O-methyltransferase; Interstitial collagenase; xanthine dehydrogenase;
References:
1. Bioorg Med Chem Lett. 2013; 23, 2, 574 - 578.; 2. Curr Med Chem. 2011; 18, 6, 808 - 829.; 3.  J Med Chem. 2016; 59, 16, 7584 - 7597.;