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N-[(5-Chloro-8-hydroxyquinolin-7-yl)(phenyl)methyl]acetamide

Technical Data

Chemical name:N-[(5-Chloro-8-hydroxyquinolin-7-yl)(phenyl)methyl]acetamide
Formula:C18H15ClN2O2
Molecular weight:326.8
CAS number:332939-46-5
SMILES:CC(=O)NC(c1ccccc1)c1cc(Cl)c2cccnc2c1O

Cat. No. BRC0696

BRC0696

Prices

1.0 mg $ 118.0
2.0 mg $ 122.0
5.0 mg $ 132.0
10.0 mg $ 147.0
20.0 mg $ 263.0
25.0 mg $ 367.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents    Antidiabetic    Anti-Inflammatory    Antiviral    Cardiovascular    Anti-infective   

Target:

Enzymes    Integrases    Enzyme-Linked Receptors    Integrin   

Description:

The compound is inhibitor of HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction (IC50 = 3 µM).

Targets:Integrase - Pc4 And Sfrs1 Interacting Protein 1 Complex [Human immunodeficiency virus 1], A disintegrin and metalloproteinase with thrombospondin motifs 5
References:
1. J. Med. Chem. 2013; 56(6), 2311-2322.; 
2. PCT Int. Appl. 2008; WO 2008014602 A1 20080207.; 
3. PCT Int. Appl. 2008; WO 2008024922 A2 20080228.;