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Pemetrexed disodium

LY-231514, LY231514, NSC-698037, Alimta

Technical Data

Chemical name:Pemetrexed disodium
Formula:C20H19N5Na2O6
Molecular weight:471.4
CAS number:150399-23-8
SMILES:[Na+].[Na+].Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@H](CCC([O-])=O)C([O-])=O)c2c(=O)[nH]1

Cat. No. BRC0650

BRC0650

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

G-Protein-Coupled Receptors (GPCRs)    Adenosine receptor    Enzymes    Dihydrofolate Reductase (DHFR)    Reductases   

Description:

Pemetrexed disodium is high-affinity dihydrofolate reductase inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Inhibits proliferation of cancer cell lines in vitro.

Targets:Thymidylate synthase, Bifunctional purine biosynthesis protein PURH, Dihydrofolate reductase, Trifunctional purine biosynthetic protein adenosine-3
References:
1. Clin Ther. 2005 Sep; 27(9):1343-82.; 
2. Anticancer Agents Med Chem. 2008; 8, 2, 205.; 
3. J. Med. Chem. 2010; 53, 18, 6539.;