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Carvedilol

BM 14190, SKF 105517

Technical Data

Chemical name:Carvedilol
Formula:C24H26N2O4
Molecular weight:406.5
CAS number:72956-09-3
SMILES:COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12

Cat. No. BRC0853

BRC0853

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antihypertensive    Cardiovascular    CNS Agents    Neurotransmitter Agents   

Target:

Kinases    Vascular endothelial growth factor (VEGF)    G-Protein-Coupled Receptors (GPCRs)    Adrenergic receptor    Enzymes    Kinases    Dehydrogenase    Enzyme-Linked Receptors    Receptor Tyrosine Kinase    Natriuretic peptide receptors    Ion Channels    Potassium channel    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity. Indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

Targets:Beta-1 adrenergic receptor, Alpha-1A adrenergic receptor, NADH dehydrogenase [ubiquinone] 1 subunit C2, Beta-2 adrenergic receptor, Vascular endothelial growth factor A, Natriuretic peptides B, Gap junction alpha-1 protein, Potassium voltage-gated channel subfamily H member 2, Vascular cell adhesion protein 1, Alpha-1D adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-2C adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-2A adrenergic receptor, E-selectin, Hypoxia-inducible factor 1-alpha, Inward rectifier potassium channel 4
References:
1. Mol. Pharmacol. 2014; 85, 4, 608 - 617.; 
2. J. Pharmacol. Exp. Ther. 1999; 290, 2, 649 - 655.; 
3. Curr Top Med Chem. 2007; 7, 2, 207 - 216.;