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Glyburide

Glibenclamide, Micronase

Technical Data

Chemical name:Glyburide
Formula:C23H28ClN3O5S
Molecular weight:494.0
CAS number:10238-21-8
SMILES:COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1

Cat. No. BRC0377

BRC0377

Prices

1.0 mg $ 86.0
2.0 mg $ 88.0
5.0 mg $ 94.0
10.0 mg $ 121.0
20.0 mg $ 146.0
25.0 mg $ 159.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antidiabetic   

Target:

Ion Channels    Potassium channel    Multidrug Transporter Inhibitors    Breast Cancer Resistance Protein (BCRP)    P-glycoprotein/ABCB1   

Description:

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production.

Targets:Sulfonylurea receptor 1, Kir6.2, G protein-activated inward rectifier potassium channel 4, ATP-binding cassette sub-family C member 9, Bile salt export pump, ATP-binding cassette sub-family A member 1, Cystic fibrosis transmembrane conductance regulator, Mitochondrial ATP-sensitive potassium channel, Carnitine O-palmitoyltransferase 1, liver isoform
References:
1. J.Gen.Physiol. 1992; 100, 573.; 
2. J.Med.Chem. 1990; 33, 1529.; 
3. Drugs. 1979; 18, 329.;