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3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Technical Data

Chemical name:3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Formula:C17H13N5O
Molecular weight:303.3
CAS number:330786-24-8
SMILES:Nc1ncnc2[nH]nc(-c3ccc(Oc4ccccc4)cc3)c12

Cat. No. BRC0545

BRC0545

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Kinases    Phosphatidylinositol 3-kinase (PDK)    Vascular endothelial growth factor (VEGF)    Kinases    Enzyme-Linked Receptors    Receptor Tyrosine Kinase    MYC (c-Myc, proto-oncogene proteins)    DNA    SUBDNA   

Description:

The compound is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor (IC50 < 10 µM) and useful synthetic intermediate in the synthesis of Ibrutinib.

Targets:Phosphatidylinositol 3-kinase regulatory subunit alpha, DNA-dependent protein kinase, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Tyrosine-protein kinase BTK, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, c-src tyrosine kinase, Vascular endothelial growth factor receptor 2, Proto-oncogene tyrosine-protein kinase LCK, Angiopoietin-1 receptor, Fibroblast growth factor receptor
References:
1. Nat. Chem. Biol. 2008; 4(11), 691-699.; 
2. PCT Int. Appl. 2001; WO 2001019829 A2 20010322.; 
3. U.S. Pat. Appl. Publ. 2002; US 20020156081 A1 20021024.;