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2-(3-{4-[(1H-indazol-5-yl)imino]-1,4-dihydropyrimidin-2-yl}phenoxy)-N-(propan-2-yl)acetamide

Technical Data

Chemical name:2-(3-{4-[(1H-indazol-5-yl)imino]-1,4-dihydropyrimidin-2-yl}phenoxy)-N-(propan-2-yl)acetamide
Formula:C22H22N6O2
Molecular weight:402.5
CAS number:1596413-63-6
SMILES:CC(C)NC(=O)COC1=CC(=CC=C1)C1=NC(C=CN1)=NC1=CC2=C(NN=C2)C=C1

Cat. No. BRC0570

BRC0570

Prices

1.0 mg $ 236.0
2.0 mg $ 245.0
5.0 mg $ 490.0
10.0 mg $ 980.0
20.0 mg $ 1692.0
25.0 mg $ 1860.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Kinases    Rho-associated protein kinase (ROCK)    Kinases    Enzyme-Linked Receptors    Receptor protein serine/threonine kinases   

Description:

The compound is ROCK1 and ROCK2 inhibitor (IC50 = 0.07 uM and > 3 uM respectively).

Targets:Rho-associated protein kinase 1; Rho-associated protein kinase 2; Casein kinase II alpha;
References:
1. PCT Int. Appl. 2015; WO 2015157556 A1 20151015.; 2. WO2012/40499, 2012; A2.; 3. WO2014/55999, 2014; A2.;