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Fludarabine phosphate

F-ara-A (NSC 312887) Phosphate, NSC-118218

Technical Data

Chemical name:Fludarabine phosphate
Formula:C10H13FN5O7P
Molecular weight:365.2
CAS number:75607-67-9
SMILES:Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O

Cat. No. BRC0349

BRC0349

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Kinases    Other kinases    Enzymes    Kinases    Reductases    DNA    SUBDNA    RNA   

Description:

Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.

Targets:DNA polymerase alpha catalytic subunit, Ribonucleoside-diphosphate reductase large subunit, DNA, Deoxycytidine kinase
References:
1. N Engl J Med. 2000 Dec 14; 343(24):1750-7.; 
2. Hematol Cell Ther. 1998 Jun; 40(3):113-8.; 
3. Blood. 2004 Jan 1; 103(1):363-5.;