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Guanethidine

Ismedine, Ismelin

Technical Data

Chemical name:Guanethidine
Formula:C10H22N4
Molecular weight:198.3
CAS number:55-65-2
SMILES:NC(N)=NCCN1CCCCCCC1

Cat. No. BRC0390

BRC0390

Prices

1.0 mg $ 83.0
2.0 mg $ 86.0
5.0 mg $ 91.0
10.0 mg $ 119.0
20.0 mg $ 205.0
25.0 mg $ 225.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antihypertensive    Cardiovascular    CNS Agents    Neurotransmitter Agents   

Target:

Transporters    Ion Pumps    Neurotransmitter transporter   

Description:

Guanethidine works by decreasing the heart rate and relaxing the blood vessels so that blood can flow more easily through the body, thereby reducing these risks. It is a postganglionic sympathetic nerve terminal blocker that prevents the release of norepinephrine from nerve terminals.

Targets:Sodium-dependent noradrenaline transporter
References:
1.Eur. J. Pharmacol. 1990; 190(1-2), 203 - 215.; 
2. Adv Biochem Psychopharmacol. 1970; 2, 109 - 132.; 
3. West.J.Med. 1980; 132(5), 430-439.; 
4. J.Bone Joint Surg.Br. 2002; 84(3), 380-386.;