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DHPG

(RS)-3,5-Dihydroxyphenylglycine;

Technical Data

Chemical name:DHPG
Formula:C8H9NO4
Molecular weight:183.2
CAS number:146255-66-5
SMILES:NC(C(O)=O)C1=CC(O)=CC(O)=C1

Cat. No. BRC1007

BRC1007

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

CNS Agents   

Target:

G-Protein-Coupled Receptors (GPCRs)    Glutamate receptor   

Description:

DHPG is an agonist of the group I metabotropic glutamate receptors, binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors. The (S)-enantiomer is about ten times more potent than the (R)-enantiomer.

Targets:Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5;
References:
1. Biochem Pharmacol. 2009; 77, 7, 1246 - 1253.; 2. Mol Pharmacol. 2003; 64, 3, 731 - 740.; 3. Neuropharmacology.  2000; 39, 7,  1119 - 1131.;