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Cyclophosphamide monohydrate

B 518, NSC 26271, Endoxan

Technical Data

Chemical name:Cyclophosphamide monohydrate
Formula:C7H17Cl2N2O3P
Molecular weight:279.1
CAS number:6055-19-2
SMILES:O.ClCCN(CCCl)P1(=O)NCCCO1

Cat. No. BRC0380

BRC0380

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

DNA    SUBDNA    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders. In cells with low levels of aldehyde dehydrogenase, cyclophosphamide acts as a prodrug since it is metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.

Targets:DNA
References:
1. J. Allergy Clin. Immunol. 2011; 127(2), 303-314.; 
2. Clev Clin J Med. 2012; 79(2), 134-140.; 
3. J.Am.Acad.Dermatol. 1984; 11, 1115-1126.; 
4. Curr. Med. Chem. 2000; 7, 693-713.;